Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma
| Autor: | Alexander Strate, Kristina Röding, Eva Geissinger, Hermann Kneitz, Marion Wobser, Sabine Roth, Verena G Frings, Andreas Rosenwald, Matthias Goebeler |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Immunofixation Pathology medicine.medical_specialty Skin Neoplasms Paraproteinemias lymphoma Dermatology Serology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases Lactate dehydrogenase lcsh:Dermatology medicine Humans Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test biology business.industry monoclonalgammopathy immunofixation Lymphoma B-Cell Marginal Zone General Medicine lcsh:RL1-803 Middle Aged Marginal zone medicine.disease Lymphoma Immunoglobulin M chemistry Immunoglobulin G 030220 oncology & carcinogenesis Serum protein electrophoresis biology.protein Primary cutaneous marginal zone lymphoma Female Immunoglobulin Light Chains Paraproteins Neoplasm Recurrence Local Immunoglobulin Heavy Chains business monoclonalimmunoglobulins Follow-Up Studies |
| Zdroj: | Acta Dermato-Venereologica, Vol 98, Iss 10, Pp 956-962 (2018) |
| ISSN: | 0001-5555 |
| DOI: | 10.2340/00015555-3016 |
| Popis: | Primary cutaneous marginal zone lymphomas (PCMZL) frequently exhibit lymphoplasmacytoid/plasmacytic differentiation, implying the capacity to produce monoclonal immunoglobulins. As these paraproteins are secreted, and thus are measurable in blood and urine, they may correlate with disease burden and serve as tumour markers reflecting therapeutic response. This study retrospectively analysed the records of 23 patients with PCMZL. During treatment and follow-up, laboratory tests, including full blood count, lactate dehydrogenase, serum protein electrophoresis and turbidimetric analyses, were conducted. Thirty-nine percent of cases showed a suspicious serum protein electrophoresis in terms of paraproteinaemia. In 44% of cases the heavy and light chain restriction in tissue samples correlated with serological findings. Altogether, 89% of the PCMZL patients with paraproteinaemia eventually experienced a relapse, in contrast to 62% of the group without paraproteinaemia. This study analysed the incidence and clinical implications of paraproteinaemia in patients with PCMZL. A clear correlation was found between paraproteinaemia, tumour relapse and therapeutic intervention. |
| Databáze: | OpenAIRE |
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