Echinococcus granulosus: Induction of T-independent antibody response against protoscolex glycoconjugates in early experimental infection
| Autor: | Verónica Fernández, Anders Örn, Gustavo Mourglia-Ettlin, Sylvia Dematteis, Hernán Carol, Adriana Baz, Alberto Nieto |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
CD4-Positive T-Lymphocytes
Glycoconjugate Immunology Cestoda Antibodies Helminth Helminthiasis Enzyme-Linked Immunosorbent Assay Epitopes Mice Antigen Echinococcosis medicine Animals Parasite hosting Echinococcus granulosus Mice Knockout chemistry.chemical_classification biology General Medicine medicine.disease biology.organism_classification Mice Inbred C57BL Infectious Diseases chemistry Immunization Antigens Helminth Immunoglobulin G CD4 Antigens biology.protein Female Parasitology Antibody Glycoconjugates |
| Zdroj: | Experimental Parasitology. 119:460-466 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/j.exppara.2008.04.024 |
| Popis: | In this work CD4-knockout mice were used as a model to analyse the role of CD4+ T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, CD4-knockout mice and C57Bl/6 mice showed similar titres of specific antibodies indicating that T-independent antibody production was quantitatively important in early infection. We have also identified an antigenic fraction from protoscoleces (E4+) which induces CD4 T cell independent antibody response in early stages of infection. In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection. |
| Databáze: | OpenAIRE |
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