Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat
| Autor: | E. Blaugrund, A. Mayk, T. Fine, Abraham Nyska, L. Litinetsky, Zipora Speiser, Sasson Cohen |
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| Rok vydání: | 2006 |
| Předmět: |
Brain Infarction
Male Time Factors medicine.medical_treatment Water maze Neuroprotection Drug Administration Schedule Brain Ischemia Brain ischemia chemistry.chemical_compound Bolus (medicine) medicine.artery Occlusion medicine Animals Rats Wistar Maze Learning Saline Biological Psychiatry Rasagiline Dose-Response Relationship Drug business.industry Infarction Middle Cerebral Artery Recovery of Function medicine.disease Rats Disease Models Animal Psychiatry and Mental health Neuroprotective Agents Treatment Outcome Neurology chemistry Anesthesia Indans Nerve Degeneration Middle cerebral artery Neurology (clinical) Cognition Disorders business |
| Zdroj: | Journal of Neural Transmission. 114:595-605 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-006-0612-5 |
| Popis: | The neuroprotective effects of intravenous rasagiline were investigated in a rat model of stroke. Middle cerebral artery (MCA) occlusion was performed in male rats and the short- (neurological severity score [NSS], infarct size), intermediate- (cognition) and long-term (necrotic area) effects were assessed. A bolus (3 mg/kg) of rasagiline followed by a 3-h infusion (3 mg/kg/h), initiated immediately after MCA occlusion, reduced infarct size by 48.6% and NSS by 32.7% relative to saline treatment. Cognitive function, tested in a water maze 2-3 weeks after occlusion, also significantly improved compared with saline-treated controls. Necrotic brain area was 35-50% smaller with rasagiline than with saline following a single bolus dose. The single bolus rasagiline dose was as effective as a rasagiline bolus followed by rasagiline infusion in short-term outcomes. The neuroprotective effect of rasagiline was fully reproducible when administered at 2 h following occlusion but not after 4 h. |
| Databáze: | OpenAIRE |
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