Exercising the hepatobiliary-gut axis. The impact of physical activity performance
| Autor: | Piero Portincasa, David Q.-H. Wang, Marcin Krawczyk, Ornella de Bari, Raquel Lunardi Baccetto, Emilio Molina-Molina |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Clinical Biochemistry Gallbladder disease Physiology Gut flora Biochemistry Metabolic equivalent Article Bile Acids and Salts 03 medical and health sciences 0302 clinical medicine Insulin resistance Cholelithiasis Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Cholecystitis Medicine Humans Healthy Lifestyle Biliary Tract Enterohepatic circulation Exercise Aged biology business.industry Microbiota Fatty liver General Medicine Middle Aged medicine.disease biology.organism_classification 3. Good health 030104 developmental biology 030211 gastroenterology & hepatology Farnesoid X receptor Female business |
| Zdroj: | European Journal of Clinical Investigation Eur J Clin Invest |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/eci.12958 |
| Popis: | Background Physical inactivity puts the populations at risk of several health problems, while regular physical activity brings beneficial effects on cardiovascular disease, mortality and other health outcomes, including obesity, glycaemic control and insulin resistance. The hepatobiliary tract is greatly involved in several metabolic aspects which include digestion and absorption of nutrients in concert with intestinal motility, bile acid secretion and flow across the enterohepatic circulation and intestinal microbiota. Several metabolic abnormalities, including nonalcoholic fatty liver as well as cholesterol cholelithiasis, represent two conditions explained by changes of the aforementioned pathways. Materials and methods This review defines different training modalities and discusses the effects of physical activity in two metabolic disorders, that is nonalcoholic fatty liver disease (NAFLD) and cholelithiasis. Emphasis is given to pathogenic mechanisms involving intestinal bile acids, microbiota and inflammatory status. Results A full definition of physical activity includes the knowledge of aerobic and endurance exercise, metabolic equivalent tasks, duration, frequency and intensity, beneficial and harmful effects. Physical activity influences the hepatobiliary-gut axis at different levels and brings benefits to fat distribution, liver fat and gallbladder disease while interacting with bile acids as signalling molecules, intestinal microbiota and inflammatory changes in the body. Conclusions Several beneficial effects of physical activity are anticipated on metabolic disorders linking liver steatosis, gallstone disease, gut motility, enterohepatic circulation of signalling bile acids in relation to intestinal microbiota and inflammatory changes. |
| Databáze: | OpenAIRE |
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