Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes
| Autor: | Peter Paul Platenburg, Cox Terhorst, Baoping Wang, Aliki Nichogiannopoulou, Steven J. Burakoff, W. Van Ewijk, Jose-Carlos Gutierrez-Ramos, Georg A. Holländer |
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| Rok vydání: | 1995 |
| Předmět: |
Aging
medicine.medical_specialty Stromal cell CD3 Complex T-Lymphocytes Cellular differentiation Bone Marrow Cells Mice Transgenic Thymus Gland Biology Immunophenotyping Mice Antigens CD Cortex (anatomy) Internal medicine medicine Animals Humans Embryonic Induction Multidisciplinary Hematopoietic Stem Cell Transplantation Nuclear Proteins Proteins T lymphocyte Mice Mutant Strains Cell biology DNA-Binding Proteins Mice Inbred C57BL Transplantation Haematopoiesis Thymocyte medicine.anatomical_structure Endocrinology Hematopoiesis Extramedullary Mice Inbred CBA Stem cell |
| Zdroj: | Nature. 373:350-353 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/373350a0 |
| Popis: | T LYMPHOCYTES of the α/β T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events1–7. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells8–10. In parallel, interactions of the thymic stromal cells with TCR-positive thymocytes are necessary for the development of the thymic medulla10–12. Comparable requirements for the differentiation of the cortex have not been defined, however. Here we analyse mutant mouse strains to assess the function of early prothymocytes in the induction of the thymic cortex. We find that animals with a developmental block at the earliest stage of T-lineage commitment lack a functional thymic cortex. This abnormality could be corrected in fetal but not adult animals by transplantation of either fetal or adult wild-type haematopoietic stem cells. Thus a developmentally restricted interaction of fetal stromal cells with early prothymocytes is required for the induction of a cortical microenvironment. In addition, a normal thymic architecture is necessary for sustained T-cell ontogeny. |
| Databáze: | OpenAIRE |
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