Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece

Autor: Alexandra Pompieri, Antonios Bertsias, Dimitrios T. Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, Michalis Tzanakakis, Christina Adamichou, Giorgis Spirou, Ioannis Tzanakis, Leda Chatzi, George Bertsias, Irini Gergianaki, Argyro Repa, Eleni Kabouraki
Přispěvatelé: Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, RS: NUTRIM - R3 - Respiratory & Age-related Health
Rok vydání: 2017
Předmět:
Male
Rural Population
Pediatrics
Urban Population
Lupus nephritis
0302 clinical medicine
Cost of Illness
Epidemiology
Lupus Erythematosus
Systemic
Immunology and Allergy
Registries
030212 general & internal medicine
DISEASE-ACTIVITY INDEX
Community based
education.field_of_study
Systemic lupus erythematosus
Greece
Incidence
Incidence (epidemiology)
Lupus Vasculitis
Central Nervous System
STAGE RENAL-DISEASE
Middle Aged
Lupus Nephritis
COLLEGE-OF-RHEUMATOLOGY
PREVALENCE
Female
Neuropsychiatric disease
Adult
medicine.medical_specialty
Adolescent
Immunology
Population
CLINICS CLASSIFICATION CRITERIA
White People
General Biochemistry
Genetics and Molecular Biology
Young Adult
03 medical and health sciences
Age Distribution
Rheumatology
medicine
Humans
DAMAGE INDEX
NEPHRITIS
education
030203 arthritis & rheumatology
business.industry
NORTHWEST GREECE
UPDATED VERSION
European population
medicine.disease
business
BILAG 2004
Zdroj: Annals of the Rheumatic Diseases, 76(12), 1992-2000. BMJ Publishing Group
ISSN: 1468-2060
0003-4967
Popis: ObjectivesSeveral population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999–2013.MethodsMultisource case-finding included patients ≥15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.ResultsOverall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (±SD) age of diagnosis at 43 (±15) years. Adjusted and crude prevalence (December 2013) was 123.4 (113.9 to 132.9) and 143 (133 to 154)/105 (165/105 in urban vs 123/105 in rural regions, pConclusionsBy the use of a comprehensive methodology, we describe the full spectrum of SLE from the community to tertiary care, with almost half of the cases having mild disease, yet with significant damage accrual. SLE is not rare, affects predominantly middle-aged women and is increasingly recognised in men. Neuropsychiatric disease is an emerging frontier in lupus prevention and care.
Databáze: OpenAIRE
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