Systemic steroid therapy for acute gout: a clinical trial and review of the literature
| Autor: | Donald A. Raddatz, Walter A. Franck, Gerald D. Groff |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Gout medicine.drug_class medicine.medical_treatment chemistry.chemical_compound Rheumatology Prednisone Adrenal Cortex Hormones Internal medicine Arthropathy Medicine Colchicine Humans Prospective Studies Prospective cohort study Chemotherapy Clinical Trials as Topic business.industry Anti-Inflammatory Agents Non-Steroidal medicine.disease Surgery Clinical trial Anesthesiology and Pain Medicine chemistry Acute Disease Corticosteroid Steroids business medicine.drug |
| Zdroj: | Seminars in arthritis and rheumatism. 19(6) |
| ISSN: | 0049-0172 |
| Popis: | Nonsteroidal antiinflammatory drugs are frequently used as initial therapy in acute gout. In select cases, however, colchicine has been recommended as an alternative therapy. A review of the literature raises significant concerns regarding the cost to benefit ratio of using colchicine in this setting. A survey of alternative forms of therapies showed few studies investigating the efficacy and side effects of a short course of oral steroids, and little support for this modality in standard textbooks. Our preliminary study suggests that a short course of oral corticosteroid therapy can be used effectively for acute gout when NSAIDs are contraindicated. The use of prednisone 30 to 50 mg or its equivalent initially, and gradually tapered over 10 days, results in clinical resolution without rebound arthropathy or steroid complications in most patients. As a result, we rarely use colchicine in the management of acute gout in our practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|