Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle
| Autor: | Maryam Abolghasemi, Soleiman Mahjoub |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
endocrine system diseases Granulosa cell Apoptosis Bioinformatics Pathogenesis Anovulation 03 medical and health sciences 0302 clinical medicine Insulin resistance Genetics medicine Hyperinsulinemia Animals Humans Insulin Endocrine system Molecular Biology Cell Proliferation business.industry Hyperandrogenism Estrogens General Medicine medicine.disease Polycystic ovary 030104 developmental biology 030220 oncology & carcinogenesis Androgens Female RNA Long Noncoding business Polycystic Ovary Syndrome |
| Zdroj: | Molecular Biology Reports. 48:3845-3851 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS. |
| Databáze: | OpenAIRE |
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