Curcumin-Loaded Self-Microemulsifying Gel for Enhancing Wound Closure
| Autor: | Shih-Lun Lo, Yu-Hsiu Yen, Chih-Yi Liu, Jiun Wen Guo, Chi-Ming Pu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Curcumin Physiology Dermatology Absorption (skin) Permeability 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine In vivo Animals Diffusion cell Skin Pharmacology Mice Inbred BALB C Wound Healing integumentary system Therapeutic effect Anti-Inflammatory Agents Non-Steroidal General Medicine 030104 developmental biology chemistry Solubility Wound closure Emulsions Wound healing Gels Ex vivo Biomedical engineering |
| Zdroj: | Skin pharmacology and physiology. 33(6) |
| ISSN: | 1660-5535 |
| Popis: | Introduction: Wound healing is a process in which damaged cutaneous tissues are repaired and is a dynamic physiological interaction involving several types of cells, tissues, and proteins. Compared with typical treatments, specifically in terms of multifunctional properties, bioactive drug-loaded wound dressing in a controlled and sustained delivery system is an advanced tool that significantly improves wound healing. Curcumin substantially enhances wound healing and prevents oxidative damage. However, the effects of this compound on improving wound healing are limited by its aqueous solubility, poor tissue absorption, and rapid metabolism. Hence, the current study aimed to investigate the therapeutic effect of curcumin-loaded self-microemulsifying gel on wound healing. Methods: Ex vivo permeation studies of the skin of BALB/c mice were performed using a diffusion cell sampling system. The in vivo therapeutic effect was investigated with a full-thickness wound model. Two 6-mm full-thickness circular wounds were created on the back of the mice via punch biopsy. Then, they received different topical gels for 12 days to enhance wound closure. Results: The curcumin-loaded self-microemulsifying gel had higher skin flux, cumulative amount, and permeability coefficient than the commercial gels. In addition, it enhanced wound healing. Conclusions: This is the first study that utilized self-microemulsifying gel loaded with curcumin as a delivery system for wound healing. However, the effect of this delivery system on wound healing or skin disease treatment should be further investigated. |
| Databáze: | OpenAIRE |
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