Suppression by Corticosterone of Adrenocorticotropin Release from Adenohypophyses Incubated in Krebs–Ringer Bicarbonate Ultrafiltered Plasma
| Autor: | Jacob Kraicer, Duncan G. Sinclair, John V. Milligan |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System medicine.medical_specialty Krebs ringer bicarbonate Physiology Bicarbonate In Vitro Techniques chemistry.chemical_compound Adrenocorticotropic Hormone Corticosterone Physiology (medical) Internal medicine medicine Animals Pharmacology Chemistry Adrenalectomy Blood Proteins General Medicine Rats Solutions Bicarbonates Endocrinology Depression Chemical Pituitary Gland Filtration Protein Binding |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 50:164-168 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | Adenohypophyses were incubated in plasma obtained from adrenalectomized rats and pressure dialyzed against Krebs–Ringer bicarbonate. Corticosterone, in concentrations between 20 and 40 μg/100 ml of ultrafiltered plasma protein, suppressed the augmented release of adrenocorticotropin induced by a crude acid extract of rat hypothalamus–stalk–median eminence. Thus corticosterone, in concentrations and conditions comparable to those found in the circulation, will act directly on the adenohypophysis to decrease its response to corticosterone-releasing factor activity. |
| Databáze: | OpenAIRE |
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