The Muscle-Bone Relationship in X-Linked Hypophosphatemic Rickets
| Autor: | Moira S. Cheung, Francis H. Glorieux, Frank Rauch, Louis-Nicolas Veilleux |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Bone density Endocrinology Diabetes and Metabolism Clinical Biochemistry Urology Context (language use) Muscle Development Models Biological Biochemistry Bone and Bones Cohort Studies Young Adult Endocrinology Bone Density Osteogenesis Predictive Value of Tests Internal medicine medicine Humans Tibia Bone Resorption Quantitative computed tomography Young adult Child Muscle Skeletal Leg Muscle Weakness medicine.diagnostic_test business.industry Biochemistry (medical) Genetic Diseases X-Linked Middle Aged Surgery Hypophosphatemic Rickets Predictive value of tests Orthopedic surgery Female Familial Hypophosphatemic Rickets Tomography X-Ray Computed business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 98:E990-E995 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2012-4146 |
| Popis: | Context: We recently found that patients with X-linked hypophosphatemic rickets (XLH) have a muscle function deficit in the lower extremities. As muscle force and bone mass are usually closely related, we hypothesized that patients with XLH could also have a bone mass deficit in the lower extremities. Objective: The study objective was to assess the muscle-bone relationship in the lower extremities of patients with XLH. Setting: The study was carried out in the outpatients department of a pediatric orthopedic hospital. Patients and Other Participants: Thirty individuals with XLH (6 to 60 y; 9 male patients) and 30 age- and gender-matched controls participated. Main Outcome Measures: Calf muscle size and density as well as tibia bone mass and geometry were assessed by peripheral quantitative computed tomography. Muscle function was evaluated as peak force in the multiple 2-legged hopping test. Results: Muscle force was significantly lower in XLH patients than in controls but muscle cross-sectional area did not differ (after adjustment for tibia length). External bone size, expressed as total bone cross-sectional area, was higher in the XLH group than in controls. The XLH cohort also had statistically significantly higher bone mineral content. Conclusions: Patients with XLH have increased bone mass and size at the distal tibia despite muscle function deficits. |
| Databáze: | OpenAIRE |
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