Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System
| Autor: | Martin J. Paterson, Rienk Eelkema, Amber L. Thompson, Wouter E. Hendriksen, Gareth O. Lloyd, Justyna M. Żurek, Vincent A. A. le Sage, Nuno Almeida, Jamie S. Foster, Jan H. van Esch, Rahul Banerjee, Vasudevan Lakshminarayanan, Helen Mulvana |
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| Rok vydání: | 2015 |
| Předmět: |
Kinetics
Supramolecular chemistry Hydrazone 010402 general chemistry 01 natural sciences Biochemistry Chemical reaction Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Computational chemistry TA164 Organic chemistry Molecule QD chemistry.chemical_classification 010405 organic chemistry Communication food and beverages General Chemistry Enol Tautomer 0104 chemical sciences chemistry F100 Chemistry Selectivity |
| Zdroj: | Journal of the American Chemical Society |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.5b06988 |
| Popis: | Simultaneous control of the kinetics and thermodynamics of two different types of covalent chemistry allows pathway selectivity in the formation of hydrogelating molecules from a complex reaction network. This can lead to a range of hydrogel materials with vastly different properties, starting from a set of simple starting compounds and reaction conditions. Chemical reaction between a trialdehyde and the tuberculosis drug isoniazid can form one, two, or three hydrazone connectivity products, meaning kinetic gelation pathways can be addressed. Simultaneously, thermodynamics control the formation of either a keto or an enol tautomer of the products, again resulting in vastly different materials. Overall, this shows that careful navigation of a reaction landscape using both kinetic and thermodynamic selectivity can be used to control material selection from a complex reaction network. |
| Databáze: | OpenAIRE |
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