A preliminary study: MUC5B promoter polymorphism and its association with IPF
| Autor: | Marwa El Sharkawy, Mohamed Shaaban Mousa, Hoda Ali Abu Yusuf, Heba Moussa, Safy Kaddah, Mohamed Galal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Promoter polymorphism Ethnic populations MUC5B Gastroenterology MUC5B gene 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Polymorphism (computer science) Internal medicine medicine 030212 general & internal medicine Allele lcsh:RC705-779 Lung business.industry Gene polymorphisms lcsh:Medical emergencies. Critical care. Intensive care. First aid Interstitial lung disease lcsh:Diseases of the respiratory system lcsh:RC86-88.9 respiratory system medicine.disease humanities respiratory tract diseases IPF medicine.anatomical_structure 030228 respiratory system business |
| Zdroj: | The Egyptian Journal of Bronchology, Vol 14, Iss 1, Pp 1-6 (2020) |
| ISSN: | 2314-8551 1687-8426 |
| DOI: | 10.1186/s43168-020-00015-0 |
| Popis: | Background The (T) allele of MUC5B gene is strongly correlated with idiopathic pulmonary fibrosis (IPF) and interstitial lung diseases (ILD) related to autoimmune conditions in Caucasians, but no data is available regarding this polymorphism in the Egyptian patients. Results This study is an observational cross-sectional study; the percentage of the (T) allele of MUC5B gene promoter in normal Egyptian persons in this study was 20%. This polymorphism is strongly related with risk for development of UIP/IPF in Egyptian patients compared to the other 2 groups (P value < 0.001). The MUC5B polymorphism has no role for developing interstitial lung disease in autoimmune diseases. Conclusions This study showed the potential role of MUC5B promoter polymorphism in IPF patients. Further multicentric studies are essential to be conducted deploying larger cohorts and different ethnic populations for further evaluation of these polymorphisms correlation. |
| Databáze: | OpenAIRE |
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