Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
| Autor: | Patricia A. Hunt, Maureen Eijpe, Ekaterina Revenkova, Rolf Jessberger, Christa Heyting, Harry Scherthan, Bodo Liebe, Craig A. Hodges |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Cohesin complex Chromosomal Proteins Non-Histone Department of Plant Sciences Centromere Cell Cycle Proteins Chromatids Biology Laboratorium voor Erfelijkheidsleer Fungal Proteins Mice Oogenesis synaptonemal complexes Meiosis Chromosome Segregation Animals Sister chromatids meiosis schizosaccharomyces-pombe Spermatogenesis Metaphase mouse Mice Knockout Recombination Genetic Genetics double-strand breaks Cohesin Synapsis association Nuclear Proteins DNA Cell Biology smc proteins Telomere segregation Cell biology Establishment of sister chromatid cohesion Chromosome Pairing condensation Meiotic sister chromatid cohesion Infertility prophase Female Chromatid Laboratory of Genetics Departement Plantenwetenschappen |
| Zdroj: | Nature Cell Biology 6 (2004) 6 Nature Cell Biology, 6(6), 555-562 |
| ISSN: | 1465-7392 |
| Popis: | Sister chromatid cohesion ensures the faithful segregation of chromosomes in mitosis and in both meiotic divisions. Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC1 beta, were suggested to be required for meiotic sister chromatid cohesion and DNA recombination. Here we show that SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II. Prophase axial elements (AEs) are markedly shortened, chromatin extends further from the AEs, chromosome synapsis is incomplete, and sister chromatid cohesion in chromosome arms and at centromeres is lost prematurely. In addition, crossover-associated recombination foci are absent or reduced, and meiosis-specific perinuclear telomere arrangements are impaired. Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements. |
| Databáze: | OpenAIRE |
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