Metabolism modulates network synchrony in the aging brain
| Autor: | Anar Amgalan, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Botond Antal, Rostam M. Razban, Ken A. Dill, Corey Weistuch |
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| Rok vydání: | 2021 |
| Předmět: |
Brain network
Aging Multidisciplinary Mechanism (biology) Brain activity and meditation Functional connectivity Models Neurological Brain Biological Sciences Biology Magnetic Resonance Imaging Younger adults Connectome Humans Aging brain sense organs Collective property skin and connective tissue diseases Neuroscience Brain aging |
| Zdroj: | Proc Natl Acad Sci U S A |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Brain aging is associated with hypometabolism and global changes in functional connectivity. Using functional MRI (fMRI), we show that network synchrony, a collective property of brain activity, decreases with age. Applying quantitative methods from statistical physics, we provide a generative (Ising) model for these changes as a function of the average communication strength between brain regions. We find that older brains are closer to a critical point of this communication strength, in which even small changes in metabolism lead to abrupt changes in network synchrony. Finally, by experimentally modulating metabolic activity in younger adults, we show how metabolism alone—independent of other changes associated with aging—can provide a plausible candidate mechanism for marked reorganization of brain network topology. |
| Databáze: | OpenAIRE |
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