Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model
| Autor: | Zeki Sekerci, Rafet Özay, Abit Aktaş, Osman Yüksel Yavuz, Hacı Mustafa Özdemir, Nuri Eralp Cetinalp, Funda Yigit |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
Epidural Space
Male medicine.medical_specialty medicine.medical_treatment Urology Rats Sprague-Dawley Cicatrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Allantoin Health Care Sciences and Services Fibrosis medicine Sprague dawley rats Animals Sağlık Bilimleri ve Hizmetleri Cerrahi Heparin business.industry Significant difference Laminectomy General Medicine Epidural fibrosis medicine.disease Epidural space Rats medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Anesthesia business 030217 neurology & neurosurgery Laminectomy rat fibrosis cepae allantoin heparin medicine.drug |
| Zdroj: | Volume: 46, Issue: 4 1233-1239 Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| DOI: | 10.3906/sag-1504-16 |
| Popis: | Background/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site. Materials and methods: Twenty-four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats were removed en bloc. Fibroblast numbers, EF, and arachnoidal involvement (AI) were evaluated. Results: The results of the treatment groups were separately compared with the control groups. The numbers of fibroblasts in the treatment groups were significantly lower than those in the control groups (P < 0.001). The grade of EF in group 2 was significantly less than that in group 1 (P < 0.05). There was no statistically significant difference regarding EF and AI grade between group 3 and group 4, and local application of the drug on EF and AI yielded better results than in the control groups. Background/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site. Materials and methods: Twenty-four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats were removed en bloc. Fibroblast numbers, EF, and arachnoidal involvement (AI) were evaluated. Results: The results of the treatment groups were separately compared with the control groups. The numbers of fibroblasts in the treatment groups were significantly lower than those in the control groups (P < 0.001). The grade of EF in group 2 was significantly less than that in group 1 (P < 0.05). There was no statistically significant difference regarding EF and AI grade between group 3 and group 4, and local application of the drug on EF and AI yielded better results than in the control groups. |
| Databáze: | OpenAIRE |
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