A Study on the Association of the Chromosome 12p13 Locus with Sporadic Late-Onset Alzheimer’s Disease in Chinese
| Autor: | You-Qiang Song, Yan Li, Ping-Yiu Yik, Zhong Li, Leung-Wing Chu |
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| Rok vydání: | 2009 |
| Předmět: |
Male
China Genotype Cognitive Neuroscience Locus (genetics) Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Gene Frequency Alzheimer Disease Genetic variation Cholesterol 24-Hydroxylase Humans Age of Onset Allele Alleles Chromosome 12 Aged Genetic association Aged 80 and over Genetics Chromosomes Human Pair 12 Reverse Transcriptase Polymerase Chain Reaction Haplotype Chromosome Psychiatry and Mental health Haplotypes Steroid Hydroxylases Female Geriatrics and Gerontology |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 27:508-512 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | Recent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer’s disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese. |
| Databáze: | OpenAIRE |
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