A Scalable Biomimetic Synthesis of Resveratrol Dimers and Systematic Evaluation of their Antioxidant Activities
| Autor: | YuXuan Lin, Shelby Allison, Mitchell H. Keylor, Derek A. Pratt, Bryan S. Matsuura, Bo Li, Corey R. J. Stephenson |
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| Rok vydání: | 2015 |
| Předmět: |
Stereoisomerism
Resveratrol Article Antioxidants Catalysis Cell Line Pallidol chemistry.chemical_compound Biomimetics Biomimetic synthesis Stilbenes Humans Organic chemistry Polycyclic Compounds Indolequinones Mode of action Biological Products Total synthesis Regioselectivity General Medicine General Chemistry humanities chemistry Yield (chemistry) Dimerization Oxidation-Reduction |
| Zdroj: | Angewandte Chemie International Edition. 54:3754-3757 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201409773 |
| Popis: | An efficient synthetic route to the resveratrol oligomers quadrangularin A and pallidol is reported. It features a scalable biomimetic oxidative dimerization that proceeds in excellent yield and with complete regioselectivity. A systematic evaluation of the natural products and their synthetic precursors as radical-trapping antioxidants has revealed that, contrary to popular belief, this mode of action is unlikely to account for their observed biological activity. |
| Databáze: | OpenAIRE |
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