Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)
| Autor: | Harriet S Chidwick, Martin A. Fascione |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Glycosylation Human pathogen Biochemistry Campylobacter jejuni Microbiology 03 medical and health sciences chemistry.chemical_compound Immune system Biosynthesis polycyclic compounds Humans Physical and Theoretical Chemistry 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Bacteria Chemistry 030302 biochemistry & molecular biology Organic Chemistry Sugar Acids biochemical phenomena metabolism and nutrition biology.organism_classification Biosynthetic Pathways Enzyme biology.protein Sugars Flagellin |
| Zdroj: | Organicbiomolecular chemistry. 18(5) |
| ISSN: | 1477-0539 |
| Popis: | The non-mammalian nonulosonic acid sugar pseudaminic acid (Pse) is present on the surface of a number of human pathogens including Campylobacter jejuni and Helicobacter pylori and other bacteria such as multidrug resistant Acinetobacter baumannii. It is likely important for evasion of the host immune sysyem, and also plays a role in bacterial motility through flagellin glycosylation. Herein we review the mechanistic and structural characterisation of the enzymes responsible for the biosynthesis of the Pse parent structure, Pse5Ac7Ac in bacteria. |
| Databáze: | OpenAIRE |
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