Atrial reverse remodeling: restitution of early tachycardia-induced alterations of atrial ion currents after termination of rapid atrial pacing in rabbits
| Autor: | Kerstin Bentz, Ralph Bosch, Christian Eick, Birgit Schreiner, Juergen Schreieck, Roman Laszlo, Agnes Konior |
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| Rok vydání: | 2012 |
| Předmět: |
Tachycardia
medicine.medical_specialty Calcium in biology Ion Channels Internal medicine medicine Animals cardiovascular diseases Patch clamp Heart Atria Atrial tachycardia Ion channel General Veterinary business.industry P wave Cardiac Pacing Artificial Atrial fibrillation medicine.disease Electrophysiology Anesthesia cardiovascular system Cardiology Rabbits medicine.symptom business |
| Zdroj: | Research in veterinary science. 94(2) |
| ISSN: | 1532-2661 |
| Popis: | Background and purpose Studies report on the reversal of electrophysiological parameters altered by atrial tachycardia after cessation of the latter. However, there is no data concerning reversal of tachycardia-induced alterations of ion currents. Reverse remodeling of atrial ion currents ( I Ca,L , I to , I sus ) was studied in our rabbit model of tachycardia-induced electrical remodeling. Methods Three groups each with four animals were built. Rapid atrial pacing (600/min) for 5 days was applied in all groups. Thereafter, different time intervals (5, 10, 20 days) were awaited before the patch clamp experiments. Results Similar to I to remodeling in our model, within 20 days after cessation of atrial tachycardia, time course of I to reverse remodeling was also U-shaped. In contrast, there was no significant recovery of I Ca,L which was initially reduced by rapid atrial pacing. Conclusion Relevance of a missing recovery of I Ca,L is likely as this current is closely linked with intracellular calcium handling. |
| Databáze: | OpenAIRE |
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