| Autor: |
Rizal Irfandi, Riswandi Riswandi, Indah Raya, Ahyar Ahmad, Ahmad Fudholi, Sulistiani Jarre, Dewi Ratih Tirto Sari, Santi Santi, Ronald Ivan Wijaya, Prihantono Prihantono |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Asian Pacific journal of cancer prevention : APJCP. 23(9) |
| ISSN: |
2476-762X |
| Popis: |
This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2.The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ADMET properties were also carried out on the complex.Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399-599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis.Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein -ACE2 receptors, and inhibiting major proteases and 3Clpro. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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