Relative importance of risk factors in bladder carcinogenesis
| Autor: | Carolyn T. Miller, C.Ineke Neutel, Rama C. Nair, Loraine D. Marrett, John M. Last, W.E. Collins |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Risk History of tuberculosis medicine.medical_specialty Allergy Tuberculosis Bladder cancer Epidemiology business.industry Smoking Negative association medicine.disease Surgery Gout Bladder carcinogenesis Sex Factors Urinary Bladder Neoplasms Internal medicine Relative risk Isoniazid medicine Humans Female business |
| Zdroj: | Journal of Chronic Diseases. 31:51-56 |
| ISSN: | 0021-9681 |
| DOI: | 10.1016/0021-9681(78)90080-2 |
| Popis: | Responses from outpatients with urological complaints were recorded in a detailed questionnaire exploring potential risk factors in bladder cancer. Subjects were subsequently classified on the basis of hospital records as cases or controls. Each of the 265 cases was matched to two controls of the same age and sex. History and treatment of tuberculosis of all subjects was verified through the four geographically adjacent tuberculosis registers. Analysis of exposures of matched triples revealed six statistically significant associations with bladder cancer in males (smoking, gout, allergies (self), allergies (family), occupational radiation exposure, and occupational exposure to chemicals) and, in females, one significant positive association (coffee consumption) and one significant negative association (allergies, self). Although the relative risk of INH exposure in females was the highest observed (3.0), the number of exposed individuals was too small to permit any meaningful conclusion. Discriminant analysis was used to rank the variables in order of their importance as potential risk factors. Statistically significant ability to discriminate cases from controls was observed in males for: (1) Allergy (family); (2) occupational exposure to radiation; (3) occupational exposure to chemicals, and (4) smoking. In females, significant discriminators were: (1) coffee consumption; (2) history of tuberculosis and INH treatment, and (3) allergy (self, protective effect). The suggestion of carcinogenic potential of a widely used prophylactic drug indicates that a large, rigorously conducted study of the association of INH with bladder cancer is in order. |
| Databáze: | OpenAIRE |
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