Predictive neurofunctional markers of attention-deficit/hyperactivity disorder based on pattern classification of temporal processing
| Autor: | Ana Cubillo, Andre F. Marquand, Michael Brammer, Katya Rubia, Heledd Hart, Anna B. Smith, Andrew Simmons |
|---|---|
| Přispěvatelé: | University of Zurich, Hart, Heledd |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Brain activation
Male medicine.medical_specialty Cerebellum Adolescent Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Audiology behavioral disciplines and activities 2738 Psychiatry and Mental Health Discrimination Psychological Predictive Value of Tests 10007 Department of Economics Basal ganglia Developmental and Educational Psychology medicine Attention deficit hyperactivity disorder Humans Child Univariate analysis Brain Mapping 3204 Developmental and Educational Psychology medicine.diagnostic_test Brain medicine.disease Magnetic Resonance Imaging 330 Economics Psychiatry and Mental health medicine.anatomical_structure Conduct disorder Attention Deficit Disorder with Hyperactivity Time Perception Feasibility Studies Nerve Net Psychology Functional magnetic resonance imaging Insula Cognitive psychology |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry, 53, 5, pp. 569-78 e1 Journal of the American Academy of Child and Adolescent Psychiatry, 53, 569-78 e1 |
| ISSN: | 0890-8567 |
| Popis: | Item does not contain fulltext OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is currently diagnosed on the basis of subjective measures, despite evidence for multi-systemic structural and neurofunctional deficits. A consistently observed neurofunctional deficit is in fine-temporal discrimination (TD). The aim of this proof-of-concept study was to examine the feasibility of distinguishing patients with ADHD from controls using multivariate pattern recognition analyses of functional magnetic resonance imaging (fMRI) data of TD. METHOD: A total of 20 medication-naive adolescent male patients with ADHD and 20 age-matched healthy controls underwent fMRI while performing a TD task. The fMRI data were analyzed with Gaussian process classifiers to predict individual ADHD diagnosis based on brain activation patterns. RESULTS: The pattern of brain activation correctly classified up to 80% of patients and 70% of controls, achieving an overall classification accuracy of 75%. The distributed activation networks with the highest delineation between patients and controls corresponded to a distributed network of brain regions involved in TD and typically compromised in ADHD, including inferior and dorsolateral prefrontal, insula, and parietal cortices, and the basal ganglia, anterior cingulate, and cerebellum. These regions overlapped with areas of reduced activation in patients with ADHD relative to controls in a univariate analysis, suggesting that these are dysfunctional regions. CONCLUSIONS: We show evidence that pattern recognition analyses combined with fMRI using a disorder-sensitive task such as timing have potential in providing objective diagnostic neuroimaging biomarkers of ADHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|