Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline
| Autor: | Corin Badiu, Ramona Cioboată, Diana Traşcă, Alice Elena Găman, Aristides M. Tsatsakis, Anca Oana Docea, Andreea Letitia Arsene, Tomescu P, Daniela Calina, Anca Ungureanu, Florin Liviu Gherghina, Nikolaos Drakoulis, Demetrios A. Spandidos |
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| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Atorvastatin Biology digestive system Gastroenterology Pentoxifylline 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine medicine medicine.diagnostic_test Fatty liver non-alcoholic fatty liver disease nutritional and metabolic diseases Articles atorvastatin General Medicine medicine.disease digestive system diseases 3. Good health pentoxifylline 030220 oncology & carcinogenesis Liver biopsy Alkaline phosphatase 030211 gastroenterology & hepatology Liver function Steatosis Dyslipidemia medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2017.4256 |
| Popis: | In this study, we aimed to evaluate the efficacy of pentoxifylline and atorvastatin in the treatment of non-alcoholic fatty liver disease (NAFLD). The study included 98 patients with histologically confirmed NAFLD divided into 2 groups as follows: group I (57 dyslipidemic patients, receiving atorvastatin 20 mg/day and group II (41 non-dyslipidemic patients, treated with pentoxifylline, 800 mg/day). The present study was conducted for a mean of 32.8±3.4 weeks. For all patients, we determined the body mass index, a liver biopsy was performed, and we measured the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), total cholesterol (TC) and triglycerides (TG) at the beginning and at the end of the study period. The NAFLD activity score (NAS) was used to evaluate the liver biopsies for steatosis, fibrosis and necroinflammation. The patients in group I exhibited a considerable reduction in ALT, AST, GGT, TC, AP and TG levels (P |
| Databáze: | OpenAIRE |
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