A new method to assess weight-bearing distribution after central nervous system lesions in rats

Autor: Vincent Pertici, Marie-Solenne Felix, Patrick Decherchi, Jeanick Brisswalter, Caroline Pin-Barre, Jérôme Laurin
Přispěvatelé: Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U901), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (... - 2019) (UNS), Institut des Sciences du Mouvement Etienne Jules Marey ( ISM ), Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ), Laboratoire Motricité Humaine Expertise Sport Santé ( LAMHESS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Université de Toulon ( UTLN ), Institut de neurobiologie de la Méditerranée ( INMED ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Behavioural Brain Research
Behavioural Brain Research, 2014, 259, pp.78-84. ⟨10.1016/j.bbr.2013.10.043⟩
Behavioural Brain Research, Elsevier, 2014, 259, pp.78-84. ⟨10.1016/j.bbr.2013.10.043⟩
Behavioural Brain Research, Elsevier, 2014, 259, pp.78-84. 〈10.1016/j.bbr.2013.10.043〉
ISSN: 0166-4328
1872-7549
Popis: International audience; The aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: (1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing the MCAO group in which focal brain ischaemia was induced by transient MCA occlusion and (2) the thoracic hemisection experiment containing the TH group in which a spinal cord hemisection was performed at the T 10 level. A Control and respective Sham groups were also included in each experiment. Not only the pressure exerted by each paw was measured but also different ratios such as: (1) the sum of the right and the left forepaws was normalized by the sum of the right and the left hindpaws (F/H), (2) the left forepaw was normalized by the right forepaw (LF/RF), (3) the left hindpaw was normalized by the right hindpaw (LH/RH). Additionally, the times spent on 3 paws and on 4 paws were measured. Only the time spent on 4 paws was shorter in the MCAO group than in the Control (p < 0.001) and in the Sham (p < 0.01) groups. The LH/RH ratio of the TH group at the 1st week was lower (p < 0.01) than the pre-surgical value. Moreover, its F/H ratio was superior (p < 0.001) to the ones of the Control and the Sham groups. Our study indicates that DWB should be more frequently used to evaluate both the severity of central nervous system traumas and the effectiveness of pharmacological and/or rehabilitation strategies.
Databáze: OpenAIRE
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