Analysis of the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters related to right heart function in detecting acute radiation-induced right heart injury
Autor: | Hongqiang Liu, Zhilin Zhang, Jinqiu Li, Shanglin Dong, Cong Wang, Likun Wang, Xiaochun Wu, Yunbo Zhang, Xin Ji, Chengbo Ren, Huan Ma |
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Rok vydání: | 2021 |
Předmět: |
Heart Injury
medicine.medical_specialty Thymoma medicine.drug_class medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans cardiovascular diseases Stage (cooking) Lung cancer Advanced and Specialized Nursing business.industry Cancer Stroke Volume medicine.disease Peptide Fragments Radiation therapy Anesthesiology and Pain Medicine medicine.anatomical_structure Heart Injuries Ventricle 030220 oncology & carcinogenesis Ventricular Function Right cardiovascular system Cardiology business Biomarkers |
Zdroj: | Annals of Palliative Medicine. 10:6455-6466 |
ISSN: | 2224-5839 2224-5820 |
Popis: | The aim of the present study was to investigate the value of parameters related to right heart function combined with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in acute radiation-induced right heart injury.Seventy patients who received chest radiotherapy (RT) in the RT department of our hospital between September 2015 and March 2019 were included in the study.Of the included 70 patients, 19, 32, 4, and 15 had thoracic esophageal cancer, central lung cancer, thymoma, and left breast cancer, respectively. The Tei index, tricuspid annular displacement, right ventricular ejection fraction, and NT-proBNP of the 70 patients were measured 1 week before RT, at weeks 2 and 4 during RT, and 4 weeks after RT. Differences in the Tei index, the tricuspid annular displacement, and NT-proBNP were significant (P0.01, P0.05, and P0.05, respectively). The Tei index significantly increased in the second week of RT. Tricuspid annular displacement decreased significantly 4 weeks after RT. NT-proBNP reached its peak value in the fourth week of RT. However, there was no significant difference in right ventricular ejection fraction (P0.05).The Tei index of the right ventricle can be used as a sensitive indicator for the early detection of right heart injury after RT for thoracic tumors. Additionally, tricuspid annular displacement can be used as an index for the early detection of right ventricular damage after RT for thoracic tumors. However, right ventricular ejection fraction showed no significant change in the early stage of right heart damage after RT. Finally, it is important to consider NT-proBNP for the detection of acute radiation-induced heart injury. In acute radiation-induced right heart injury, the combined application of right ventricular Tei index, tricuspid annular displacement, and NT-proBNP is clinically relevant. |
Databáze: | OpenAIRE |
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