Tissue oxygenation index measured using spatially resolved spectroscopy correlates with changes in cerebral blood flow in newborn lambs
| Autor: | Flora Y. Wong, Makoto Nakamura, Theodora Alexiou, Vojta Brodecky, Adrian M. Walker |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Sheep Spectroscopy Near-Infrared business.industry Spatially resolved Hemodynamics Brain Blood flow Oxygenation Critical Care and Intensive Care Medicine Oxygen Consumption Cerebral blood flow Animals Newborn Anesthesia Internal medicine Intensive care Cerebrovascular Circulation medicine Cardiology Animals Cerebral perfusion pressure business Oxygen saturation circulatory and respiratory physiology |
| Zdroj: | Intensive care medicine. 35(8) |
| ISSN: | 1432-1238 |
| Popis: | Abnormal cerebral haemodynamics in very preterm infants undergoing neonatal intensive care have been associated with adverse outcome, but cerebral blood flow (CBF) is difficult to assess at the cotside. Spatially resolved spectroscopy (SRS) continuously measures cerebral tissue oxygen saturation expressed as tissue oxygenation index (TOI, %), and TOI would reflect changes in CBF with constant cerebral metabolic demand. We aimed to evaluate the relationship between simultaneous measurements of CBF (Transonic System) and TOI (Hamamatsu NIRO-200) in newborn lambs (n = 8). We hypothesised that alterations in CBF of different magnitudes and frequencies would be reflected as changes of TOI in both time domain and frequency domain analyses. A silicon cuff positioned around the common brachiocephalic artery was inflated to induce 10–30% reductions in cerebral perfusion pressure so as to produce mild-to-moderate variations of CBF. Relationships between changes in CBF and TOI were evaluated in the time domain (Pearson correlation) and frequency domain (Coherence). In time domain analysis, there was significant correlation between ΔTOI (%) and ΔCBF (%) (R 2 = 0.69, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink