Molecular epidemiology of influenza B virus and implications in immunization strategy, Southern Brazil
| Autor: | Sonia Mara Raboni, Luciane A. Pereira, Mayra Marinho Presibella, Irina Nastassja Riediger, Luine R. Vidal, Maria do Carmo Debur, Bruna Lapinscki, Meri Bordignon Nogueira |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Influenza vaccine 030106 microbiology Biology Antibodies Viral medicine.disease_cause H5N1 genetic structure Virus Young Adult 03 medical and health sciences Influenza Human Epidemiology medicine Humans Child Epidemics Aged General Veterinary General Immunology and Microbiology Molecular epidemiology Reverse Transcriptase Polymerase Chain Reaction Public Health Environmental and Occupational Health Middle Aged Virology Influenza A virus subtype H5N1 Vaccination Influenza B virus Cross-Sectional Studies Infectious Diseases Influenza Vaccines Child Preschool Epidemiological Monitoring Human mortality from H5N1 RNA Viral Molecular Medicine Female Immunization Seasons Brazil |
| Zdroj: | Vaccine. 36:107-113 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2017.11.033 |
| Popis: | Epidemiological indicators have shown the substantial impact of influenza B (Flu B) on the development of severe acute respiratory infection (SARI) and on mortality rates. In Brazil, the trivalent vaccine, composed of only one Flu B lineage is available. We investigated Flu B infections in clinical samples collected by the epidemiological surveillance service of Paraná State, Brazil, from 2013 to 2016. The Flu B lineages Yamagata- (B/Yam) and Victoria-like (B/Vic) were identified using the qRT-PCR assay, and notification forms were reviewed. Among 379 Flu B positive samples evaluated, 370 (98%) were characterized as B/Yam or B/Vic lineages. Both co-circulated with a frequency of 47% and 53%, respectively. B/Yam infected equally both genders, while B/Vic was more frequent in females (71%). The median age of patients infected by B/Vic (23y; 11-35) was lower than that of patients infected by B/Yam (32y; 12-50). Mismatch between the vaccine and the circulating strain was observed in the 2013 season, with a high number of SARI cases. B/Vic lineage was associated with a larger number of SARI cases (62%), while B/Yam with influenza-like illness (ILI) (61%). Differences were observed in the strains circulating in separate regions of Paraná State. B/Vic was prevalent in the northwestern (67%) and B/Yam in the southeastern region (60%). The unpredictability of Flu B lineage circulation causes a substantial increase in severe disease during epidemics in a vaccine mismatch season. In addition, the differences in the epidemiological profile of the target population of Flu B infections in relation to other respiratory viruses, as well as among the B/Vic and B/Yam lineages may also be associated to an increase in disease burden. These findings have direct consequences on vaccination strategies. Therefore, further molecular epidemiology studies of Flu B in Brazil are required to corroborate these primary results. |
| Databáze: | OpenAIRE |
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