Chronic maternal stress inhibits the capacity to up-regulate placental 11β-hydroxysteroid dehydrogenase type 2 activity
| Autor: | Paul M. Plotsky, K. V. Thrivikraman, Leonie Welberg |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Placenta Endocrinology Diabetes and Metabolism Dehydrogenase Basal (phylogenetics) Maternal stress Endocrinology Pregnancy 11-beta-Hydroxysteroid Dehydrogenase Type 2 Internal medicine Animals Medicine Chronic stress 11beta-Hydroxysteroid Dehydrogenase Type 2 Fetus business.industry medicine.disease Rats Up-Regulation Enzyme Activation Rats Inbred Lew Chronic Disease Gestation Female business Stress Psychological |
| Zdroj: | Journal of Endocrinology. 186:R7-R12 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.1.06374 |
| Popis: | This study investigated the effects of acute and chronic restraint stress during the third week of pregnancy on placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in rats. Acute exposure to stress on gestational day 20 immediately up-regulated placental 11beta-HSD2 activity by 160%, while chronic stress from day 14 to day 19 of pregnancy did not significantly alter basal 11beta-HSD2 activity. However, the latter reduced the capacity to up-regulate placental 11beta-HSD2 activity in the face of an acute stressor by 90%. Thus, immediate up-regulation of 11beta-HSD2, the feto-placental barrier to maternal corticosteroids, may protect the fetus against stress-induced high levels of maternal corticosteroids, but exposure to chronic stress greatly diminishes this protection. |
| Databáze: | OpenAIRE |
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