Current clinical guideline definitions of airflow obstruction and COPD overdiagnosis in primary care
| Autor: | Annelies Lucas, Ivo Smeele, Yvonne F. Heijdra, Joke Grootens, C. van Weel, Bart Thoonen, T. J. van Boxem, Tjard Schermer |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Vital capacity Implementation Science [NCEBP 3] Pulmonary Disease Chronic Obstructive FEV1/FVC ratio Predictive Value of Tests Forced Expiratory Volume Internal medicine Effective Primary Care and Public Health [EBP 3] Humans Medicine Lung volumes Overdiagnosis Aged Aged 80 and over COPD Cardiovascular diseases [NCEBP 14] Primary Health Care medicine.diagnostic_test business.industry Effective primary care and public health [NCEBP 7] Guideline Middle Aged Airway obstruction medicine.disease Bronchodilator Agents Pathogenesis and modulation of inflammation [N4i 1] Airway Obstruction Practice Guidelines as Topic Cardiology Physical therapy Female Microbial pathogenesis and host defense [UMCN 4.1] business |
| Zdroj: | European Respiratory Journal, 32, 4, pp. 945-52 European Respiratory Journal, 32, 945-52 |
| ISSN: | 0903-1936 |
| Popis: | Contains fulltext : 69188.pdf (Publisher’s version ) (Closed access) The aim of the present study was to establish the agreement between two recommended definitions of airflow obstruction in symptomatic adults referred for spirometry by their general practitioner, and investigate how rates of airflow obstruction change when pre-bronchodilator instead of post-bronchodilator spirometry is performed. The diagnostic spirometric results of 14,056 adults with respiratory obstruction were analysed. Differences in interpretation between a fixed 0.70 forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) cut-off point and a sex- and age-specific lower limit of normal cut-off point for this ratio were investigated. Of the subjects, 53% were female and 69% were current or ex-smokers. The mean post-bronchodilator FEV(1)/FVC was 0.73 in males and 0.78 in females. The sensitivity of the fixed relative to the lower limit of normal cut-off point definition was 97.9%, with a specificity of 91.2%, positive predictive value of 72.0% and negative predictive value of 99.5%. For the subgroup of current or ex-smokers aged > or =50 yrs, these values were 100, 82.0, 69.2 and 100%, respectively. The proportion of false positive diagnoses using the fixed cut-off point increased with age. The positive predictive value of pre-bronchodilator airflow obstruction was 74.7% among current or ex-smokers aged > or =50 yrs. The current clinical guideline-recommended fixed 0.70 forced expiratory volume in one second/forced vital capacity cut-off point leads to substantial overdiagnosis of obstruction in middle-aged and elderly patients in primary care. Using pre-bronchodilator spirometry leads to a high rate of false positive interpretations of obstruction in primary care. |
| Databáze: | OpenAIRE |
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