Gastric carcinoids and their precursor lesions. A histologic and immunohistochemical study of 23 cases
| Autor: | Ji-Yao Yu, G. Franzin, Mauro Papotti, Francesco Paolo Pilato, Carla Davoli, Cesare Bordi, Giorgio Gardini, Giuseppe Baruzzi, M. T. Baggi, Giuseppe Zamboni, Gianni Bussolati |
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| Rok vydání: | 1991 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty Pathology biology Atrophic gastritis business.industry Stomach Chromogranin A Enteroendocrine cell Hyperplasia medicine.disease Gastroenterology digestive system diseases medicine.anatomical_structure Oncology Submucosa Internal medicine biology.protein medicine Synaptophysin business Gastrin |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19910201)67:3<663::aid-cncr2820670323>3.0.co;2-l |
| Popis: | A histologic and immunohistochemical study was carried out in 23 unselected nonantral gastric carcinoids and their precursor lesions classified according to Solcia et al. None of the patients showed Zollinger-Ellison syndrome. Two variants of carcinoids showing distinctive pathologic and pathogenetic characteristics were identified on the basis of presence or absence of associated chronic atrophic gastritis type A (A-CAG). Chronic atrophic gastritis type A was found in 19 cases showing either single or multiple neoplasms, tumor extension limited to the mucosa or submucosa, consistent endocrine cell precursor changes in extratumoral mucosa, and consistent hypergastrinemia and/or G cell hyperplasia. Associated precursor lesions were only hyperplastic in all but two cases with single carcinoids whereas they were also dysplastic in all but one case with multiple carcinoids. The four tumors arising in nonatrophic mucosa were all single, more aggressive, and not associated with extratumoral endocrine cell proliferations or with signs of gastrin hypersecretion. Tumor cells were diffusely immunoreactive for chromogranin A and synaptophysin but usually negative for chromogranin B or HISL-19. Scattered serotonin cells were found in ten carcinoids. They were more frequent in infiltrating than in intramucosal tumors as were the less represented pancreatic polypeptide cells whereas the reverse was found for alpha-subunit-containing cells. These results are of relevance for tumor pathogenesis and may provide the rationale for a less aggressive therapeutic approach in the patients. |
| Databáze: | OpenAIRE |
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