En Route to 2-(Cyclobuten-1-yl)-3-(trifluoromethyl)-1H-indole
| Autor: | Marko Krivec, Martin Gazvoda, Janez Košmrlj, Zdenko Časar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Indole test
Drug Efavirenz Trifluoromethyl Reverse-transcriptase inhibitor 010405 organic chemistry media_common.quotation_subject Organic Chemistry 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry medicine 0210 nano-technology medicine.drug media_common |
| Zdroj: | The Journal of Organic Chemistry. 83:2486-2493 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.8b00100 |
| Popis: | A six-step synthetic route from 4-chloro-2-methylaniline to 5-chloro-2-(cyclobut-1-en-1-yl)-3-(trifluoromethyl)-1H-indole (1) has been reported. Compound 1a is a key impurity of reverse transcriptase inhibitor efavirenz, an important anti-HIV/AIDS drug. Synthetic challenges, dead ends, and detours are discussed. |
| Databáze: | OpenAIRE |
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