The enigmatic role of IL-38 in inflammatory diseases

Autor: Mathilde Harel, T Garraud, Marie-Astrid Boutet, Frédéric Blanchard, Benoit Le Goff
Přispěvatelé: maurice, sandrine, Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238] (Phy-Os), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes), Département de Rhumatologie (Rhumato - HD - NANTES), Hôtel-Dieu de Nantes, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work was supported by Inserm, the Arthritis Foundation, the French Society of Rheumatology, Pfizer and the Région Pays de la Loire (Bioregate)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)
Rok vydání: 2017
Předmět:
0301 basic medicine
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Immunology
Arthritis
Inflammation
Context (language use)
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Psoriatic arthritis
Mice
Psoriasis
medicine
Immunology and Allergy
Animals
Humans
Spondylitis
Ankylosing
Receptors
Cytokine
Receptor
IL-1F
Ankylosing spondylitis
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
business.industry
Interleukins
Arthritis
Psoriatic
Toll-Like Receptors
Receptors
Interleukin-1
Cell Differentiation
Receptors
Interleukin
medicine.disease
3. Good health
IL-38
030104 developmental biology
Cytokine
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Th17 Cells
medicine.symptom
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Interleukin-1
Zdroj: Cytokine and Growth Factor Reviews
Cytokine and Growth Factor Reviews, Elsevier, 2018, Epub ahead of print. ⟨10.1016/j.cytogfr.2018.01.001⟩
ISSN: 1879-0305
1359-6101
DOI: 10.1016/j.cytogfr.2018.01.001⟩
Popis: International audience; IL-38 is the most recently discovered cytokine of the IL-1 family and is considered a potential inhibitor of the IL-1 and Toll-like receptor families. IL-38 exerts anti-inflammatory properties, especially on macrophages, by inhibiting secretion of pro-inflammatory cytokines, leading to reduced T-lymphocyte TH17 maturation. IL-38 has been studied most extensively in the context of chronic inflammatory diseases, particularly arthritis, where it is considered an attractive new drug candidate. IL-38 research has entered a new phase, with the realization that IL-38 is important in the pathophysiology of TH17 dependent-diseases (psoriasis, psoriatic arthritis and anky-losing spondylitis). In this review, we provide a critical evaluation of several controversial issues concerning IL-38 function and regulation. There is effectively contrasting data regarding IL-38: it is produced in conditions such as apoptosis, necrosis or inflammation, but data is lacking regarding IL-38 processing and biological function. Furthermore, the receptor for IL-38 has yet to be identified, although three candidate receptors – IL-1R1, IL-36R and IL-1RAPL1–have been proposed. Future studies will hopefully uncover new aspects of this enigmatic cytokine.
Databáze: OpenAIRE
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