Effects of intravenous administration of tiletamine-zolazepam, alfaxalone, ketamine-diazepam, and propofol for induction of anesthesia on cardiorespiratory and metabolic variables in healthy dogs before and during anesthesia maintained with isoflurane
| Autor: | Katherine F. Scollan, Riebold Tw, Chiara E. Hampton, D. David Sisson, Ronald E. Mandsager, Nicole L. LeBlanc |
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| Rok vydání: | 2019 |
| Předmět: |
Male
040301 veterinary sciences Pregnanediones Sevoflurane 0403 veterinary science Dogs Heart Rate Reference Values Heart rate medicine Animals Anesthesia Ketamine Cardiac Output Infusions Intravenous Propofol Anesthetics Tiletamine Diazepam Isoflurane General Veterinary business.industry Alfaxalone 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine Zolazepam 040201 dairy & animal science Drug Combinations Anesthetics Inhalation Anesthetic Female business medicine.drug |
| Zdroj: | American Journal of Veterinary Research. 80:33-44 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.80.1.33 |
| Popis: | OBJECTIVE To compare effects of tiletamine-zolazepam, alfaxalone, ketamine-diazepam, and propofol for anesthetic induction on cardiorespiratory and acid-base variables before and during isoflurane-maintained anesthesia in healthy dogs. ANIMALS 6 dogs. PROCEDURES Dogs were anesthetized with sevoflurane and instrumented. After dogs recovered from anesthesia, baseline values for cardiorespiratory variables and cardiac output were determined, and arterial and mixed-venous blood samples were obtained. Tiletamine-zolazepam (5 mg/kg), alfaxalone (4 mg/kg), propofol (6 mg/kg), or ketamine-diazepam (7 and 0.3 mg/kg) was administered IV in 25% increments to enable intubation. After induction (M0) and at 10, 20, 40, and 60 minutes of a light anesthetic plane maintained with isoflurane, measurements and sample collections were repeated. Cardiorespiratory and acid-base variables were compared with a repeated-measures ANOVA and post hoc t test and between time points with a pairwise Tukey test. RESULTS Mean ± SD intubation doses were 3.8 ± 0.8 mg/kg for tiletamine-zolazepam, 2.8 ± 0.3 mg/kg for alfaxalone, 6.1 ± 0.9 mg/kg and 0.26 ± 0.04 mg/kg for ketamine-diazepam, and 5.4 ± 1.1 mg/kg for propofol. Anesthetic depth was similar among regimens. At M0, heart rate increased by 94.9%, 74.7%, and 54.3% for tiletamine-zolazepam, ketamine-diazepam, and alfaxalone, respectively. Tiletamine-zolazepam caused higher oxygen delivery than propofol. Postinduction apnea occurred in 3 dogs when receiving alfaxalone. Acid-base variables remained within reference limits. CONCLUSIONS AND CLINICAL RELEVANCE In healthy dogs in which a light plane of anesthesia was maintained with isoflurane, cardiovascular and metabolic effects after induction with tiletamine-zolazepam were comparable to those after induction with alfaxalone and ketamine-diazepam. |
| Databáze: | OpenAIRE |
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