Evidence for hypothalamic ketone bodies sensing: impact on food intake and peripheral metabolic responses in mice
| Autor: | Luc Pellerin, Lionel Carneiro, Xavier Fioramonti, Corinne Leloup, Cendrine Repond, Sarah Geller, Audrey Hébert |
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| Přispěvatelé: | Department of Physiology, Université de Lausanne (UNIL), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB), the Swiss Fond National de Recherche Scientifique through grant no. 31003A-140957, a grant from the Societe Francophone du Diabete in 2014., University of Lausanne, Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Université de Bourgogne ( UB ), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine obesity nervous-system Physiology [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition Endocrinology Diabetes and Metabolism Ketone Bodies Energy homeostasis Eating Mice bodies Homeostasis Glucose homeostasis oxidative stress Agouti-Related Protein Neuropeptide Y Phosphorylation monocarboxylate transporters 2. Zero hunger [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] fat mass Hypothalamus Ketone bodies Starvation response ketogenic mediterranean diet weight-loss medicine.medical_specialty beta-hydroxybutyrate Biology Diet High-Fat 03 medical and health sciences Insulin resistance rat-brain Physiology (medical) Internal medicine medicine [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Animals glucose homeostasis Adenylate Kinase/metabolism Agouti-Related Protein/metabolism Eating/drug effects Eating/physiology Energy Metabolism/drug effects Energy Metabolism/physiology Gluconeogenesis/drug effects Gluconeogenesis/physiology Hypothalamus/drug effects Hypothalamus/metabolism Insulin Resistance/physiology Ketone Bodies/pharmacology Mice Inbred C57BL Neuropeptide Y/metabolism Phosphorylation/drug effects energy homeostasis Adenylate Kinase Gluconeogenesis medicine.disease 030104 developmental biology Endocrinology low-carbohydrate Insulin Resistance Energy Metabolism [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | AJP-Endocrinology and Metabolism AJP-Endocrinology and Metabolism, American Physiological Society, 2016, 310 (2), pp.E103-E115. ⟨10.1152/ajpendo.00282.2015⟩ American Journal of Physiology. Endocrinology and Metabolism, vol. 310, no. 2, pp. E103-E115 AJP-Endocrinology and Metabolism, American Physiological Society, 2016, 310 (2), pp.E103-E115. 〈10.1152/ajpendo.00282.2015〉 |
| ISSN: | 0193-1849 1522-1555 |
| DOI: | 10.1152/ajpendo.00282.2015⟩ |
| Popis: | Monocarboxylates have been implicated in the control of energy homeostasis. Among them, the putative role of ketone bodies produced notably during high-fat diet (HFD) has not been thoroughly explored. In this study, we aimed to determine the impact of a specific rise in cerebral ketone bodies on food intake and energy homeostasis regulation. A carotid infusion of ketone bodies was performed on mice to stimulate sensitive brain areas for 6 or 12 h. At each time point, food intake and different markers of energy homeostasis were analyzed to reveal the consequences of cerebral increase in ketone body level detection. First, an increase in food intake appeared over a 12-h period of brain ketone body perfusion. This stimulated food intake was associated with an increased expression of the hypothalamic neuropeptides NPY and AgRP as well as phosphorylated AMPK and is due to ketone bodies sensed by the brain, as blood ketone body levels did not change at that time. In parallel, gluconeogenesis and insulin sensitivity were transiently altered. Indeed, a dysregulation of glucose production and insulin secretion was observed after 6 h of ketone body perfusion, which reversed to normal at 12 h of perfusion. Altogether, these results suggest that an increase in brain ketone body concentration leads to hyperphagia and a transient perturbation of peripheral metabolic homeostasis. |
| Databáze: | OpenAIRE |
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