Free radical-scavenging activities of oligomeric proanthocyanidin from Rhodiola rosea L. and its antioxidant effects in vivo
| Autor: | Wen Zhao, Hui-Ling Li, Hong-Wei Hao, Zhi-Ping Yin, Lei Ma, Qian Zhou |
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| Rok vydání: | 2014 |
| Předmět: |
Antioxidant
medicine.medical_treatment Plant Science Biochemistry Antioxidants Analytical Chemistry Superoxide dismutase chemistry.chemical_compound Mice Picrates In vivo Malondialdehyde medicine Animals Proanthocyanidins chemistry.chemical_classification Glutathione Peroxidase biology Lipid peroxide Chemistry Superoxide Superoxide Dismutase Glutathione peroxidase Organic Chemistry Biphenyl Compounds Free Radical Scavengers biology.organism_classification Rhodiola rosea biology.protein Rhodiola |
| Zdroj: | Natural product research. 28(24) |
| ISSN: | 1478-6427 |
| Popis: | This study aimed to determine the antioxidant activity of oligomeric proanthocyanidin from Rhodiola rosea L. (OPCRR). The free radical-scavenging activities exhibited by OPCRR, as determined by using 1,1-diphenyl-2-picrylhydrazyl, hydroxyl radical and superoxide anion (√[Formula: see text]) scavenging assays, were greater than that of vitamin C. The effects of OPCRR on the antioxidant enzymes activity and lipid peroxide content in vivo were evaluated through three observation biomarkers, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, heart, liver and brain tissues in mice. The OPCRR significantly enhanced the SOD and GSH-Px activities, and reduced the MDA content in mice. These results indicated that the OPCRR has a great potential to be a natural antioxidant due to its considerable antioxidant activities in vitro and in vivo. |
| Databáze: | OpenAIRE |
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