Fat necrosis and parenchymal scarring after breast-conserving surgery and radiotherapy with an intraoperative electron or fractionated, percutaneous boost: a retrospective comparison
| Autor: | Uwe Heindrichs, Michael Pinkawa, Michael J. Eble, Berthold Wein, Daniela Piroth, Richard Holy, Marc D. Piroth, Karin Fischedick |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Percutaneous medicine.medical_treatment Breast Neoplasms Electrons Mastectomy Segmental Cicatrix Breast cancer Surgical oncology Parenchyma Breast-conserving surgery Medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Fat necrosis Fat Necrosis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Breast tissue Intraoperative Care business.industry Carcinoma Ductal Breast Radiotherapy Dosage General Medicine Middle Aged medicine.disease Prognosis Combined Modality Therapy Radiation therapy Carcinoma Lobular Oncology Female Radiotherapy Adjuvant Radiology Neoplasm Grading business Follow-Up Studies Mammography |
| Zdroj: | Breast cancer (Tokyo, Japan). 21(4) |
| ISSN: | 1880-4233 |
| Popis: | The aim of this retrospective analysis was to evaluate mammographic changes such as fat necroses and parenchymal scarring in the breast tissue within the first 3 years after breast-conserving surgery (BCS) and whole-breast irradiation with an additional intraoperative electron boost (IO-B) versus fractionated percutaneous boost (FP-B). A total of 53 breast cancer patients (stage I/II) treated between 2006 and 2008 were included. All patients underwent BCS followed by fractionated whole-breast radiotherapy with a total dose and single dose of 50.4 and 1.8 Gy. Twenty patients had 10 Gy IO-B using electrons, and 33 patients were treated with a FP-B with 10.8 Gy. The IO-B was performed using the mobile linear accelerator NOVAC 7. The follow-up mammograms were focused on fat necroses, parenchymal scarring and skin thickening. Fat necroses occurred significantly more frequently in IO-B patients compared to FP-B patients (50.0 vs. 18.2 %). The fat necroses were mammographically detected a median of 17 versus 23 months post-surgery for the IO-B versus FP-B patients. The median size of fat necroses was 24 (14–30) mm for the IO-B group and 14 (4–53) mm for the FP-B group. Parenchymal scarring in the grade 3–4 tumor bed area was seen significantly more frequently in the IO-B patients (55.0 vs. 21.2 %). Skin thickening did not differ significantly. The IO-B led to significantly more fat necroses and local restricted parenchymal scarring in our analysis. |
| Databáze: | OpenAIRE |
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