Intramolecular Amidation: Synthesis of Novel Imidazo[2,1-b][1,3,4]thiadiazole and Imidazo[2,1-b][1,3]thiazole Fused Diazepinones

Autor:	V. S. Hegde, Gundurao Kolavi, Imtiyaz Ahmed Khazi
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Stereochemistry Chemistry Intramolecular force Organic Chemistry Drug Discovery General Medicine Ring (chemistry) Thiazole Biochemistry
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200630183
Popis:	Novel heterocyclic systems 2-alkyl/aryl-9-(2-hydroxybenzylidene)-7,9-dihydro-8H-[1,3,4]thiadiazolo[2′,3′:2,3]imidazo[4,5-d][1,2]diazepin-8-one and 9-(2-hydroxy-benzylidene)-3,3-dimethyl-3,4,7,9-tetrahydro-2H-11-thia-4b,6,7,10-tetraazaindeno[1,2-a]azulene-1,8-dione are synthesized via an intramolecular amidation reaction. An interesting ring opening and cyclization of 2-alkyl/aryl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde and 6,6-dimethyl-8-oxo-2-(2-oxo-2H-chromen-3-yl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole-3-carbaldehyde are discussed.
Databáze:	OpenAIRE
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