Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer
| Autor: | Ove B. Schaffalitzky de Muckadell, Ming Tan, Maiken Thyregod Joergensen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pancreatic ductal adenocarcinoma
endocrine system diseases business.industry Pancreatic Intraepithelial Neoplasia precursor lesions familial pancreatic cancer network-based analysis digestive system diseases Gene expression Familial Pancreatic Cancer gene expression Cancer research Medicine Original Article business sporadic pancreatic cancer |
| Zdroj: | Tan, M, Schaffalitzky, O B & Jørgensen, M T 2020, ' Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer ', Journal of Pancreatic Cancer, vol. 6, no. 1, pp. 73-84 . https://doi.org/10.1089/pancan.2020.0007 Journal of Pancreatic Cancer |
| ISSN: | 2475-3246 |
| DOI: | 10.1089/pancan.2020.0007 |
| Popis: | Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade familial pancreatic cancer (FPC)-related PanIN lesions may characterize the molecular events during the progression from familial PanIN to PDAC.Materials and Methods: We performed weighted gene coexpression network analysis (WGCNA) to identify clusters of coexpressed genes associated with FPC-related PanIN lesions in 13 samples with PanIN-2/3 from FPC predisposed individuals, 6 samples with PDAC from sporadic pancreatic cancer (SPC) patients, and 4 samples of normal donor pancreatic tissue.Results: WGCNA identified seven differentially expressed gene (DEG) modules and two commonly expressed gene (CEG) modules with significant enrichment for Gene Ontology (GO) terms in FPC and SPC, including three upregulated (p Conclusion: FPC-related PanIN lesions exhibit a common molecular basis with SPC as shown by gene network activities and commonly expressed high-connectivity hub genes. The differential molecular pathology of FPC and SPC involves multiple coexpressed gene clusters enriched for GO terms including extracellular activities and mitochondrion function. |
| Databáze: | OpenAIRE |
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