Testosterone control of brain and anterior pituitary β-adrenergic receptors
| Autor: | Samuel M. McCann, G.D. Snyder, S.L. Petrovic, John K. McDonald |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Hypothalamus Biology Binding Competitive General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Anterior pituitary Pituitary Gland Anterior Internal medicine Receptors Adrenergic beta medicine Animals Testosterone Castration General Pharmacology Toxicology and Pharmaceutics Receptor Brain Rats Inbred Strains General Medicine Luteinizing Hormone Prolactin Rats Endocrinology medicine.anatomical_structure chemistry Follicle Stimulating Hormone Luteinizing hormone Hormone |
| Zdroj: | Life Sciences. 34:2399-2406 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(84)90428-4 |
| Popis: | Orchidectomy of adult albino rats resulted in a quick, (approximately 70%) increase in the density of beta-adrenergic receptors in the anterior pituitary gland within the first day. There was a concurrent rapid increase in plasma levels of pituitary gonadotropins. The beta-receptor density continued to increase slowly for at least 16 days after castration, but it could be lowered significantly to the levels of sham-operated animals by treatment with testosterone (3 mg/kg/day) beginning on the fourth day after castration and continuing for 4 days. This treatment also completely reversed the elevation in plasma levels of luteinizing hormone (LH), and significantly reduced the circulating follicle-stimulating hormone (FSH) levels. Prolactin levels were not significantly altered by the treatments used in these studies. Most of the beta-adrenergic receptors induced by orchidectomy in the anterior pituitary were shown, using a beta 1-selective antagonist, practolol, or a beta 2-selective antagonist, IPS-339, to be of the beta 2-subtype. The density of the beta-adrenergic receptors in the cerebral cortex also increased significantly (10-24%) after castration, and returned to the levels of sham-operated animals following treatment with testosterone. No significant change in the density of the beta-adrenergic receptors in the hypothalamus resulted from either castration or testosterone replacement. |
| Databáze: | OpenAIRE |
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