Synthesis and Evaluation of a New Ganglionic Blocking Agent*

Autor:	F.W. Schueler, H. H. Keasling
Rok vydání:	1954
Předmět:	Ganglionic blocking agent medicine.medical_specialty Chemistry Ganglionic Blockers Pharmacology Autonomic Agents chemistry.chemical_compound Endocrinology Autonomic Drugs Internal medicine Muscarinic acetylcholine receptor medicine Mydriasis Moiety Hexamethonium medicine.symptom
Zdroj:	Journal of the American Pharmaceutical Association (Scientific ed.). 43:98-101
ISSN:	0095-9553
DOI:	10.1002/jps.3030430208
Popis:	Details concerning the synthesis and pharmacologic evaluation of a new hexamethonium ganglionic blocking agent containing a "built-in" muscarinic moiety are described. The inclusion of this latter moiety may be regarded as an attempt to increase parasympathetic tone toward the alleviation of such undesirable side actions as constipation and mydriasis produced by hexamethonium.
Databáze:	OpenAIRE
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