Expression of Emmprin and matriptase in esophageal squamous cell carcinoma: Correlation with clinicopathological parameters
| Autor: | Ann Chen, H. Chiang, J.-S. Jin, M.-F. Cheng, Lai-Fa Sheu, W.-C. Tsai, W.-H. Lee, Ching Tzao |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Esophageal Neoplasms Cell Extracellular matrix Carcinoma medicine Humans Matriptase Esophagus Aged Oligonucleotide Array Sequence Analysis Aged 80 and over Metalloproteinase biology business.industry Serine Endopeptidases Gastroenterology Cell Differentiation General Medicine Middle Aged medicine.disease Immunohistochemistry stomatognathic diseases medicine.anatomical_structure Tumor progression Basigin Carcinoma Squamous Cell Disease Progression biology.protein Female business |
| Zdroj: | Diseases of the Esophagus. 19:482-486 |
| ISSN: | 1442-2050 1120-8694 |
| Popis: | Extracellular matrix metalloproteinase inducer (EMMPRIN) and the type II transmembrane serine protease, matriptase, are expressed in several human cancers and play an important role in tumor progression. The aim of the present study was to investigate the immuno-staining patterns of EMMPRIN and matriptase in patients with esophageal squamous cell carcinomas (SCC) and correlate the percentage tumor staining with tumor differentiation and clinical parameters. EMMPRIN and matriptase immunoreactivity was seen on the cell membrane and in the cytoplasm of tumor cells in all 41 cases of esophageal SCC evaluated. The percentage tumor staining of EMMPRIN was 48 +/- 3% for well differentiated, 73 +/- 3% for moderately differentiated, and 92 +/- 3% for poorly differentiated esophageal SCC. Higher percentage tumor staining with EMMPRIN correlated significantly with poorly differentiated esophageal SCC (P < 0.05). The percentage tumor staining with matriptase correlated significantly with tumor differentiation (52 +/- 3% for well differentiated, 85 +/- 2% for moderately differentiated, and 88 +/- 3% for poorly differentiated esophageal SCC). Additionally, higher percentage tumor staining with matriptase was significantly correlated with the advanced N and M stages (P < 0.05). Our results demonstrate that EMMPRIN and matriptase are over-expressed in esophageal SCC and are correlated with advanced clinicopathological stages. Pharmacological agents targeting EMMPRIN and matriptase expressions may be beneficial in the treatment of esophageal SCC. |
| Databáze: | OpenAIRE |
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