The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

Autor: Sara Vogrin, Yohann Wittrant, Véronique Coxam, Gustavo Duque, Oddom Demontiero, Mostafa Alderghaffar, Ebrahim Bani Hassan, Fabien Wauquier
Přispěvatelé: Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne, Western Health, Department Medicine Western Health, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Duque, G., AIMSS Australian Institute for Musculoskeletal Science, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_specialty
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Senile osteoporosis
Bone density
Osteoporosis
Adipose tissue
030209 endocrinology & metabolism
aging
fish oil
marrow adipose tissue
osteoporosis
SAMP8 mouse
03 medical and health sciences
Mice
0302 clinical medicine
Bone Density
Bone Marrow
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Femur
Geriatry and gerontology
030304 developmental biology
Adiposity
Borage
0303 health sciences
business.industry
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
Cell Biology
X-Ray Microtomography
Fish oil
medicine.disease
Dietary Fats
Disease Models
Animal
medicine.anatomical_structure
Endocrinology
Lipotoxicity
Adipose Tissue
Dietary Supplements
Gériatrie et gérontologie
Female
Bone marrow
business
Autre (Sciences du Vivant)
Research Paper
Zdroj: Aging
Aging, 2019, 11 (18), pp.7938-7947. ⟨10.18632/aging.102299⟩
Aging, Impact Journals, 2019, 11 (18), pp.7938-7947. ⟨10.18632/aging.102299⟩
Aging (Albany NY)
Aging 18 (11), 7938-7947. (2019)
ISSN: 1945-4589
DOI: 10.18632/aging.102299⟩
Popis: Purpose: Marrow adipose tissue (MAT) expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow (HBM) atrophy. Fish oil and borage oil (rich in ω3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. However, whether preservation of bone mass in this progeria model is associated with MAT volumes remains unknown. Results: MAT volume fraction (MAT%) showed a negative association with hematopoietic bone marrow (HBM%;r=-0.836, p9 /group) were allocated into 4 categories and fed a control ration, FO-, sunflower oil (SFO)- and borage oil-enriched diets for lifetime. Femurs were scanned using microcomputed tomography (μCT) and bone, MAT, and HBM volumes were determined using an image analysis software.
Databáze: OpenAIRE
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