Preparation of Chitosan and Glycol Chitosan Coated Magnetic Nanoparticles Loaded with Carboplatin as Anticancer Drug
| Autor: | Ayşe Karakeçili, Ali Mert Erdek, Ceren Atila Dinçer, Nuray Yıldız |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Fe3O4-OA nanoparticles
chitosan / glycol chitosan coating carboplatin anticancer drug loading drug release Nanocomposite 020209 energy Mühendislik 02 engineering and technology 021001 nanoscience & nanotechnology Chitosan chemistry.chemical_compound Engineering chemistry Bromide Transmission electron microscopy 0202 electrical engineering electronic engineering information engineering Magnetic nanoparticles Fourier transform infrared spectroscopy 0210 nano-technology Cytotoxicity Nuclear chemistry Superparamagnetism |
| Zdroj: | Volume: 22, Issue: 4 1017-1022 Politeknik Dergisi |
| ISSN: | 2147-9429 |
| Popis: | Surface modified Fe3O4 nanoparticles (Fe3O4-OA) with an average diameter of 10 nm were synthesized, coated by chitosan (CS) and glycol chitosan (GCS), thus magnetic polymer nanocomposites were obtained. The magnetic nanostructures were analyzed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and vibrating sample magnetometer (VSM). All magnetic structures synthesized in this study exhibited superparamagnetic properties. Loading carboplatin (CPt) as anticancer drug to Fe3O4-OA-GCS nanocomposites were carried out with 13.17 % drug content and 38 % encapsulation efficiency. The cytotoxicity studies were occured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on L929 mouse fibroblasts and MCF-7 human breast cancer cells. Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 µg/ml drug concentrations during 72 h. |
| Databáze: | OpenAIRE |
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