A case study of disseminated histoplasmosis linked to common variable immunodeficiency
| Autor: | Acir Rachid, Francisco Luiz Gomide Mafra Magalhães, Paulo C. Loffy, Lucila Stange Rezende, Suzelle Freitas de Moura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Adult Male Tuberculosis Histoplasma immunoglobulins lcsh:QR1-502 Disease Asymptomatic lcsh:Microbiology lcsh:Infectious and parasitic diseases Fatal Outcome Disseminated histoplasmosis Medicine Humans lcsh:RC109-216 Encapsulated bacteria Histoplasmosis business.industry Common variable immunodeficiency fungi common variable immunodeficiency food and beverages medicine.disease Mediastinitis Infectious Diseases medicine.anatomical_structure Immunology medicine.symptom business Respiratory tract |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 7, Iss 4, Pp 268-272 (2003) Brazilian Journal of Infectious Diseases, Vol 7, Iss 4, Pp 268-272 |
| ISSN: | 1678-4391 1413-8670 |
| Popis: | Histoplasma capsulatum, a ground fungus, can infect humans, normally in endemic areas; the resulting disease can be asymptomatic or it can have a benign development, but in rare cases it can develop into a serious clinical condition and can even be fatal. Its most characteristic initial location is in the lungs, resembling tuberculosis, often accompanied by mediastinitis and an exuberant fibrotic response. The spread of this infection can be caused by the concomitance of another illness that alters the immunological balance. Sometimes such an association is not clear. Therefore, disseminated histoplasmosis is defined as a clinical condition where the fungus is present in more than one location. Common variable immunodeficiency is characterized by a generalized failure in the synthesis of antibodies, leading the affected individuals to present recurrent infections, especially those caused by encapsulated bacteria, most often involving the respiratory tract. We studied a serious case of disseminated histoplasmosis, accompanied by common variable immunodeficiency, observed at the Infirmary of the department of Medical Practice of the Federal University at Parana Hospital das Clinicas. |
| Databáze: | OpenAIRE |
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