Development of Morphine Glucuronidation in Premature Neonates
| Autor: | Malcolm I. Levene, R. Hartley, M. Green, Quinn Mw, J.A. Rushforth |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Morphine Derivatives Chemotherapy Morphine Chemistry medicine.medical_treatment Infant Newborn Glucuronidation Gestational Age Kinetics Pharmacokinetics Anesthesia Recien nacido Pediatrics Perinatology and Child Health medicine Birth Weight Humans Gestation Female Infant Premature Developmental Biology medicine.drug |
| Zdroj: | Neonatology. 66:1-9 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000244083 |
| Popis: | In premature neonates (25–34 weeks gestation) who were given morphine intravenously during the first 24 h of life, only morphine, and morphine-3-glucuronide (M3G) were detected in plasma obtained after a 2-hour loading infusion, but morphine-6-glucuronide (M6G) could also be quantified following 24 h of continuous infusion. M3G/morphine and M6G/morphine plasma concentration ratios increased significantly with increasing birth weight. However, the M6G/M3G plasma concentration ratio decreased with increasing birth weight (and gestational age), thus providing the first indication in vivo of the differential development of uridinediphosphate glucuronosyltransferases in humans. |
| Databáze: | OpenAIRE |
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