Glucose impairment and ghrelin gene variants are associated to cognitive dysfunction
| Autor: | M, Mora, M L, Mansego, M, Serra-Prat, E, Palomera, X, Boquet, J F, Chaves, M, Puig-Domingo, I, Villarroya |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty Polymorphism Single Nucleotide Cohort Studies Apolipoproteins E Internal medicine Diabetes mellitus Genotype medicine Humans Genetic Association Studies Aged Aged 80 and over Metabolic Syndrome Psychiatric Status Rating Scales business.industry Anthropometry medicine.disease Obesity Ghrelin Cross-Sectional Studies Endocrinology Spain Ageing Female Geriatrics and Gerontology Metabolic syndrome Cognition Disorders business Body mass index |
| Zdroj: | Aging Clinical and Experimental Research. 26:161-169 |
| ISSN: | 1720-8319 |
| DOI: | 10.1007/s40520-014-0203-5 |
| Popis: | Cognitive state and brain volume have been related to body mass index, abdominal fat, waist–hip ratio, components of metabolic syndrome (MS) and ghrelin. Genetic variations within the ghrelin gene have been recently associated to MS. The aim of our study was to investigate cognitive state by Mini-Mental State Examination (MMSE) in relation to MS components (ATP-III criteria) and ghrelin gene polymorphisms in dwelling individuals aged ≥70. 280 subjects (137 men/143 women, age 77.03 ± 5.92) from the Mataro Ageing Study were included. Individuals were phenotypically characterized by anthropometric variables, lipids, glucose, blood pressure and MMSE. SNPs -501AC (rs26802), −994CT (rs26312), −604GA (rs27647), M72L (rs696217) and L90G (rs4684677) of the ghrelin gene were studied. Genotypes were determined by polymerase chain reaction and SNapshot minisequencing. 22.1 % had MMSE |
| Databáze: | OpenAIRE |
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