Intertwined and Finely Balanced: Endoplasmic Reticulum Morphology, Dynamics, Function, and Diseases
| Autor: | Viki Allan, Hannah T. Perkins |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Nuclear Envelope Dynein Review Endoplasmic Reticulum Legionella pneumophila Microtubules kinesin Structure-Activity Relationship Microtubule anomalous diffusion Organelle morphology Animals Humans Biology (General) membrane contact site (MCS) Cytoskeleton dynein biology Endoplasmic reticulum morphology Endoplasmic reticulum Membrane Proteins General Medicine dynamics biology.organism_classification Lipids Cell biology Mitochondria endoplasmic reticulum (ER) Mitochondrial Membranes Kinesin Function (biology) microtubule |
| Zdroj: | Cells Cells, Vol 10, Iss 2341, p 2341 (2021) Perkins, H T & Allan, V 2021, ' Intertwined and Finely Balanced: Endoplasmic Reticulum Morphology, Dynamics, Function, and Diseases ', Cells, vol. 10, no. 9, 2341 . https://doi.org/10.3390/cells10092341 |
| ISSN: | 2073-4409 |
| Popis: | The endoplasmic reticulum (ER) is an organelle that is responsible for many essential subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like regions in the perinuclear region are linked to the nuclear envelope. It is becoming apparent that the complex morphology and dynamics of the ER are linked to its function. Mutations in the proteins involved in regulating ER structure and movement are implicated in many diseases including neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). The ER is also hijacked by pathogens to promote their replication. Bacteria such as Legionella pneumophila and Chlamydia trachomatis, as well as the Zika virus, bind to ER morphology and dynamics-regulating proteins to exploit the functions of the ER to their advantage. This review covers our understanding of ER morphology, including the functional subdomains and membrane contact sites that the organelle forms. We also focus on ER dynamics and the current efforts to quantify ER motion and discuss the diseases related to ER morphology and dynamics. |
| Databáze: | OpenAIRE |
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