Inhibitors of protein synthesis and the central regulation fo body temperature
| Autor: | Samardzic R, Beleslin Db |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Ataxia Time Factors Myoclonic Jerk Nerve Tissue Proteins Cerebral Ventricles Injections Cellular and Molecular Neuroscience Internal medicine medicine Protein biosynthesis Animals Human body temperature Pharmacology Dactinomycin CATS Chemistry Hypothermia Endocrinology Anesthesia Cerebral ventricle Cats Female medicine.symptom medicine.drug Body Temperature Regulation |
| Zdroj: | Neuropharmacology. 14(2) |
| ISSN: | 0028-3908 |
| Popis: | A single injection of actinomycin D, an inhibitor of protein synthesis, into the cerebral ventricle of unanaesthetized cats, caused a long lasting fall in body temperature. Threshold effects were obtained with doses as low as 0.5 μg. Body temperature began to fall after a latency of a few days and reached a minimum level of approximately 25°C, 5–10 days after administration. This low temperature was maintained for 1–2 days. During hypothermia, from which the animals did not recover, aggression, ataxia, rigidity, tremor, myoclonic jerks and convulsions sometimes developed. The results indicate that protein synthesis in the brain is an important factor in the maintainance of normal body temperature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|