Epicardial and Perihepatic Fat as Cardiometabolic Risk Predictors in Girls with Turner Syndrome: A Cardiac Magnetic Resonance Study
| Autor: | Donia M. Sobh, Nanees Salem, Ahmed M. Tawfik, Nihal M. Batouty, Shimaa R. Hendawy, Basma Gadelhak, Wafaa Laimon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatric Obesity
medicine.medical_specialty Waist Adolescent epicardial fat Endocrinology Diabetes and Metabolism perihepatic fat Intra-Abdominal Fat Overweight Pediatrics metabolic syndrome RJ1-570 Diseases of the endocrine glands. Clinical endocrinology Body Mass Index Endocrinology Insulin resistance Internal medicine Abdomen medicine Humans Chemerin Child biology business.industry Cardiometabolic Risk Factors RC648-665 medicine.disease Magnetic Resonance Imaging Obesity Case-Control Studies Pediatrics Perinatology and Child Health turner syndrome biology.protein Cardiology Original Article Egypt Female Waist Circumference Metabolic syndrome medicine.symptom business Pericardium Body mass index Dyslipidemia |
| Zdroj: | JCRPE, Vol 13, Iss 4, Pp 408-417 (2021) Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| DOI: | 10.4274/jcrpe.galenos.2021.2021.0030 |
| Popis: | Objective: Turner syndrome (TS) patients are at high risk of cardiometabolic disorders. Cardiometabolic risk factors are more commonly related to visceral rather than total body adiposity. Adipocytokines have been explored as a potential link between obesity and obesity-related cardiometabolic dysfunction. This study explored the validity of epicardial fat-thickness (EFT) and perihepatic fat-thickness (PHFT) measurement as cardiometabolic-risk predictors in TS-girls in relation to standard obesity-indices and metabolic syndrome (MetS) components. Methods: Forty-six TS girls and twenty-five controls (10-16 years) were subdivided into two age-groups (10 to less than 13 and 13-16). Participants were assessed for body mass index (BMI) Z-scores, waist circumference (WC), total-fat mass (FM) and trunk-FM by bioimpedance-technique, EFT and PHFT by cardiovascular magnetic resonance, lipid-profile, homeostasis model assessment of insulin resistance (HOMA-IR), and serum chemerin. MetS was defined according to International Diabetes Federation criteria. Results: Overweight/obesity and MetS were detected in 45.7% and 37% of TS-girls respectively. BMI Z-score, WC, total-FM, trunk-FM, EFT and PHFT values were significantly higher in TS-age groups compared to age-matched control groups, being more pronounced in the older group when TS-girls had been exposed to estrogen. Dyslipidemia, higher HOMA-IR, chemerin, EFT and PHFT values were observed in lean-Turner compared to BMI-Z-matched controls. EFT and PHFT were significantly correlated with chemerin and several components of MetS. EFT at a cut-off-value of 6.20 mm (area under the curve=0.814) can predict MetS in TS-girls. Conclusion: TS-girls displayed an adverse cardiometabolic profile during late childhood and adolescence. EFT and PHFT are emerging cardiometabolic risk predictors in TS-patients. Excess EFT rather than total body adiposity may contribute to altered metabolic profile among lean-Turner patients. |
| Databáze: | OpenAIRE |
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